Structural characterisation of SARM in axon degeneration and cell death

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dSarm / Sarm 1 Is Required for Activation of an Injury - Induced Axon Death Pathway

Immun. 65, 2396 (1997). 7. N. H. Salzman, D. Ghosh, K. M. Huttner, Y. Paterson, C. L. Bevins, Nature 422, 522 (2003). 8. B. Ericksen, Z. Wu, W. Lu, R. I. Lehrer, Antimicrob. Agents Chemother. 49, 269 (2005). 9. N. H. Salzman et al., Nat. Immunol. 11, 76 (2010). 10. See supplementary materials on Science Online. 11. A. J. Bäumler, R. M. Tsolis, P. J. Valentine, T. A. Ficht, F. Heffron, Infect. I...

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Axon degeneration has been proposed to be a new therapeutic target for neurodegenerative diseases, because it usually occurs earlier than neuronal cell body death with a distinct active program from apoptosis and necrosis. Overexpression of Wld(S) or Nmnats (nicotinamide mononucleotide adenylytransferase, EC2.7.7.1) has been demonstrated to delay axon degeneration initiated by various insults. ...

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Sarm1-mediated axon degeneration requires both SAM and TIR interactions.

Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a wide range of neurological disorders. In an RNAi-based screen performed in cultured mouse DRG neurons, we observed strong suppression of injury-induced axon degeneration upon knockdown of Sarm1 [SARM (sterile α-motif-containi...

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Axon pruning and neuronal cell death constitute two major regressive events that enable the establishment of fully mature brain architecture and connectivity. Although the cellular mechanisms for these two events are thought to be distinct, recent evidence has indicated the direct involvement of axon guidance molecules, including semaphorins, netrins, and ephrins, in controlling both processes....

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ژورنال

عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances

سال: 2017

ISSN: 2053-2733

DOI: 10.1107/s205327331708740x